In histology, zymogen granules can be visualized using various staining techniques. Hematoxylin and eosin (H&E) staining is commonly used, where the granules appear as basophilic structures within the cytoplasm of acinar cells. Electron microscopy provides more detailed images, revealing the dense core and membrane structure of the granules. Immunohistochemistry can also be employed to specifically label zymogen proteins, aiding in the study of their distribution and abundance within tissues.
