How are viral infections diagnosed histologically?
Viral infections can cause cytopathic effects (CPEs) that are visible under a microscope. These effects include cell enlargement, multinucleation, and inclusion bodies. For example, Herpes Simplex Virus (HSV) infection can result in multinucleated giant cells with intranuclear inclusion bodies. Immunohistochemistry (IHC) can also be employed to detect viral antigens within tissues.
