In their inactive form, SREBPs are located in the membranes of the endoplasmic reticulum (ER). Upon activation, they are transported to the Golgi apparatus, where they undergo two sequential proteolytic cleavages. The cleaved, active forms of SREBPs then translocate to the nucleus, where they bind to specific sterol regulatory elements (SREs) in the promoter regions of target genes to regulate their transcription.
