In histology, studying NK cells involves various techniques: - Immunohistochemistry (IHC): This technique is used to detect specific NK cell markers in tissue sections. Antibodies against CD56, CD16, and NKp46 are commonly used. - Flow Cytometry: While not a histological technique per se, flow cytometry is often used in conjunction with histological studies to quantify and characterize NK cells in tissue samples. - Microscopy: Advanced microscopy techniques, including fluorescence and confocal microscopy, allow for the detailed visualization of NK cells and their interactions with other cell types within tissues.