How are Drug Induced Changes Detected in Histological Studies?

Drug induced changes are detected using various histological techniques. Hematoxylin and eosin (H&E) staining is a common method used to visualize general tissue architecture and cellular morphology. Specialized stains, such as Masson's trichrome for fibrosis or Periodic acid-Schiff (PAS) for glycogen accumulation, can highlight specific tissue alterations. Immunohistochemistry (IHC) can be employed to detect specific proteins or markers of cellular stress and damage.