Yes, rigidity can be modified through various interventions. Therapeutic approaches such as collagenase injections have been used to reduce tissue stiffness in conditions like Dupuytren's contracture. Additionally, physical therapies and mechanical loading exercises can influence tissue rigidity by promoting remodeling of the ECM and cytoskeleton. Advances in tissue engineering also allow for the design of biomaterials with specific mechanical properties to modulate rigidity in regenerative medicine applications.
