Several factors can influence the rigidity of cells and tissues. The composition of the extracellular matrix (ECM) plays a crucial role as it provides structural support and determines the mechanical properties of tissues. The presence of collagen, elastin, and other ECM proteins can significantly affect tissue rigidity. Additionally, the cytoskeleton within cells, composed of actin filaments, microtubules, and intermediate filaments, also contributes to cellular stiffness. Changes in these components can lead to variations in rigidity.
