The implementation of a negative control is crucial for several reasons: 1. Validation of Specificity: It confirms that the staining or signal observed in the test samples is due to the specific binding of the primary antibody to the target antigen. 2. Background Noise Identification: It helps in identifying and quantifying any background staining or non-specific binding. 3. Quality Control: It serves as a quality control measure to assess the overall quality and reliability of the histological procedure.
