In histology, the presence and type of bilirubin can indicate various pathologies. For example, elevated levels of unconjugated bilirubin could suggest hemolytic anemia, while high levels of conjugated bilirubin might indicate bile duct obstruction or liver diseases like hepatitis or cirrhosis. Histological examination of liver biopsy samples can reveal bilirubin accumulation in hepatocytes and bile canaliculi, providing crucial diagnostic information.
