In histology, HLAs are significant because they are involved in the immune response and tissue compatibility. They are crucial for:
- Organ Transplantation: Matching donor and recipient HLAs can reduce the risk of organ rejection. - Disease Association: Certain HLA types are associated with autoimmune diseases like rheumatoid arthritis, Type 1 diabetes, and celiac disease. - Forensic Science: HLA typing can be used in forensic investigations to identify individuals.
