What are the Histopathological Indicators of Inflammation in Metabolic Syndromes?
Chronic inflammation is a key feature of metabolic syndromes. Histopathologically, this can be indicated by:
- Macrophage Infiltration: Presence of macrophages in adipose tissue, often forming crown-like structures around dead adipocytes. - Cytokine Expression: Increased expression of inflammatory cytokines such as IL-6, TNF-α, and MCP-1. - Fibrosis: In the liver, fibrosis is a common feature in advanced stages of NAFLD/NASH, marked by the deposition of extracellular matrix proteins.
