In the kidney, SGLT2 plays a critical role in ensuring that glucose is efficiently reabsorbed from the filtrate back into the bloodstream, preventing glucose loss in the urine. SGLT2 reabsorbs approximately 90% of filtered glucose, while SGLT1 reabsorbs the remaining 10%. This process is vital for maintaining normal blood glucose levels and preventing glucosuria, a condition characterized by the presence of glucose in the urine.
