FcαRs are primarily expressed on the surface of myeloid cells, including neutrophils, eosinophils, monocytes, macrophages, and some dendritic cells. They can also be found on Kupffer cells in the liver and Langerhans cells in the skin. These receptors are strategically located to interact with IgA antibodies, which are abundant in mucosal areas, thus providing a first line of defense against pathogens.
