Consumables should be replaced based on manufacturer recommendations, usage frequency, and observed wear or degradation. For example: - Reagents and chemicals: Typically replaced as per their expiry date or when they show signs of contamination or precipitation. - Embedding cassettes: Generally, these are single-use and should be discarded after one use. - Microtome blades: Should be replaced when they become dull or after a set number of sections, as specified by the manufacturer. - Paraffin wax: Replaced when it becomes contaminated or after a certain number of embedding cycles. - Staining kits: Replaced based on the expiry date or when staining quality declines.