Immunohistochemistry (IHC): This technique uses antibodies to detect specific proteins in tissue sections, allowing researchers to visualize where and how a drug acts within tissues. In situ hybridization (ISH): ISH allows for the detection of specific nucleic acid sequences within tissue samples, helping to identify gene expression patterns related to drug response. Electron microscopy: This provides ultra-high-resolution images of cellular structures, offering detailed insights into drug-tissue interactions at the subcellular level. Fluorescence microscopy: Used to observe the localization and interaction of fluorescently labeled molecules within tissues, aiding in the study of drug mechanisms.
