IDPs are implicated in numerous diseases due to their involvement in critical cellular processes. For example:
- Cancer: IDPs such as p53 and BRCA1 are key regulators of cell cycle and apoptosis. Mutations or dysregulation of these IDPs can lead to uncontrolled cell proliferation. - Neurodegenerative Diseases: Proteins like α-synuclein and tau, which are IDPs, are associated with Parkinson's and Alzheimer's diseases. Their aggregation and misfolding are crucial aspects of these conditions. - Cardiovascular Diseases: IDPs are involved in heart muscle function and signaling pathways. Alterations in these proteins can contribute to heart diseases.
