Software plays a critical role in quantitative histology by automating and simplifying data analysis. Some popular software tools include: - ImageJ: An open-source image processing program that can perform a variety of quantitative analyses. - CellProfiler: A free software designed for high-throughput image analysis, particularly useful for cell and tissue imaging. - Aperio: A digital pathology platform that provides tools for quantifying IHC staining and other histological features.