Mitochondria are the powerhouses of the cell, responsible for generating ATP through oxidative phosphorylation. In endurance activities, efficient ATP production is crucial. Any histological evidence of mitochondrial dysfunction, such as reduced mitochondrial density or impaired oxidative enzymes, can lead to decreased endurance. Mitochondrial myopathies are a group of disorders that directly affect mitochondrial function, leading to symptoms like muscle weakness and decreased endurance.
