What Role Does Fixation Play in Preventing Tissue Damage?
Fixation is a critical step in histological processing that preserves tissue structure and prevents degradation. Proper fixation stabilizes cellular components, making tissues more resilient to subsequent processing steps. Key aspects of fixation include:
Choice of Fixative: Different tissues may require specific fixatives, such as formalin, glutaraldehyde, or alcohol-based solutions. Fixation Time: Adequate fixation time ensures complete penetration and stabilization of tissues. Temperature and pH: Optimal fixation conditions, including temperature and pH, help maintain tissue integrity.
