What Role Do Lipids Play in Skin Barrier Function?
In the context of skin histology, the lipid barrier, specifically found in the stratum corneum of the epidermis, is crucial for preventing water loss and protecting against environmental assaults. The lipids in this layer, primarily ceramides, free fatty acids, and cholesterol, form a lamellar structure that is highly impermeable to water and other substances. Disruption of this lipid composition can lead to skin disorders such as atopic dermatitis and psoriasis.