What role do ICCs play in gastrointestinal disorders?
Dysfunction or loss of ICCs is associated with various gastrointestinal motility disorders. Conditions such as diabetic gastroparesis, chronic constipation, and Hirschsprungâs disease have been linked to alterations in ICCs. For instance, a decrease in ICC numbers or impaired ICC function can lead to disrupted slow wave activity and ineffective peristalsis, contributing to symptoms of these disorders.
