What Role do Endothelial Cells Play in Vascular Diseases?
Endothelial cells line the interior surface of blood vessels and play a crucial role in vascular health. Histologically, endothelial dysfunction is a key feature in many vascular diseases:
- Endothelial Activation: Changes in endothelial cell morphology and function, often marked by increased expression of adhesion molecules and inflammatory cytokines. - Endothelial Damage: Loss of endothelial integrity, leading to increased permeability and thrombosis. - Neoangiogenesis: Formation of new blood vessels, which can occur in response to ischemia or chronic inflammation.
