What Pathologies are Associated with Imbalances in Osteoblast and Osteoclast Activity?
Imbalances in the activities of osteoblasts and osteoclasts can lead to several bone disorders. Conditions like osteoporosis result from excessive osteoclast activity and insufficient osteoblast activity, leading to decreased bone density and increased fracture risk. Conversely, conditions such as osteopetrosis result from defective osteoclast function, leading to overly dense but brittle bones.
