Several mechanisms can contribute to slow growth in tissues:
Cell Cycle Regulation: Alterations in cell cycle regulators such as cyclins and cyclin-dependent kinases (CDKs) can slow down cell proliferation. Cellular Senescence: Cells may enter a state of senescence, where they stop dividing but remain metabolically active. Apoptosis: Programmed cell death can balance cell proliferation and prevent uncontrolled growth. Extracellular Matrix (ECM) Interaction: The ECM can influence cell behavior, including proliferation and differentiation.
