What mechanisms are involved in skin wound healing?
To understand the cellular dynamics during skin wound healing, researchers employed confocal microscopy and immunofluorescence staining. The studies revealed a coordinated response involving keratinocytes, fibroblasts, and macrophages. Key findings include the rapid proliferation of keratinocytes at the wound edge and the migration of fibroblasts and macrophages to the wound site, which facilitate re-epithelialization and extracellular matrix remodeling, respectively.