The nuclear lamina is a dense fibrillar network located just inside the inner nuclear membrane. It is composed of intermediate filament proteins called lamins. The nuclear lamina provides mechanical support to the nuclear envelope, helps maintain nuclear shape, and anchors nuclear pore complexes. It is also involved in DNA replication, transcription, and chromatin organization. Mutations in lamin genes can lead to a group of genetic disorders known as laminopathies, which affect various tissues and organs.
