Lymphangiogenesis, the formation of new lymphatic vessels, is another crucial aspect related to lymphatic intravasation. Tumors often induce lymphangiogenesis by secreting growth factors like VEGF-C and VEGF-D. These new vessels provide additional routes for cancer cells to disseminate. Histologically, lymphangiogenesis can be identified by the increased density of lymphatic vessels around the tumor, which can be stained using markers such as D2-40.
