Several histological studies have been conducted to understand the cellular and tissue-level effects of acyclovir. These studies often focus on tissues with high viral loads or those at risk of drug-induced toxicity. For example, histological analyses of renal tissue in patients undergoing high-dose acyclovir therapy have revealed tubular damage and interstitial nephritis in some cases. Similarly, liver biopsies may show mild to moderate hepatocellular changes in patients with pre-existing liver conditions. Overall, these studies highlight the importance of histological assessments in the comprehensive evaluation of antiviral therapies like acyclovir.
