Alterations in TrkA signaling are implicated in various diseases. For instance, mutations in the TrkA gene can cause congenital insensitivity to pain with anhidrosis (CIPA), a rare genetic disorder. Overexpression of TrkA has been linked to certain types of cancers, such as neuroblastoma. Conversely, reduced TrkA activity is associated with neurodegenerative diseases like Alzheimer's disease.
