What is the Role of the Enteric Nervous System in Motility Disorders?
The enteric nervous system (ENS) is often referred to as the "second brain" and is critical for regulating GI motility. It comprises two major plexuses: the myenteric (Auerbach's) plexus and the submucosal (Meissner's) plexus. The myenteric plexus primarily controls muscle contractions, while the submucosal plexus regulates enzyme secretion and blood flow. Histological damage or loss of neurons in these plexuses can severely impair motility.
