What is the Role of Mast Cell Degranulation in Allergic Reactions?
In allergic reactions, mast cell degranulation is a key event. When an allergen binds to IgE antibodies on a mast cell, it triggers degranulation, releasing histamine and other mediators. This leads to classic allergic symptoms such as itching, swelling, and redness. In severe cases, it can result in anaphylaxis, a life-threatening systemic reaction.
