What is the Role of Histology in Lysosomal Storage Diseases?
Lysosomal storage diseases are characterized by the accumulation of undigested substrates within lysosomes due to enzyme deficiencies. Histologically, this can be observed as enlarged cells with a foamy appearance. For example, in Gaucher's disease, histology shows macrophages filled with glucocerebroside, giving them a distinct "wrinkled tissue paper" appearance.
