What Is the Role of Histology in Diagnosing Deficiencies?
Histological examination is a valuable tool in diagnosing vitamin B12 and folate deficiencies. Bone marrow biopsies can reveal megaloblastic changes, while peripheral blood smears can identify hypersegmented neutrophils. Biopsies from the gastrointestinal tract can show atrophic changes, and spinal cord sections can reveal demyelination. These histological findings, combined with clinical and laboratory data, can confirm the diagnosis and guide appropriate treatment.
