What are the Histological Features of Vitamin B12 and Folate Deficiency?
In vitamin B12 or folate deficiency, the bone marrow shows characteristic changes. Megaloblastic anemia is a hallmark feature, characterized by the presence of abnormally large, immature red blood cells called megaloblasts. These cells have a distinctive appearance with a large nucleus and an open chromatin pattern. Additionally, hypersegmented neutrophils (white blood cells with more than five nuclear lobes) are often observed in peripheral blood smears.
