What is the Role of Follicular Dendritic Cells in SHM?
Follicular dendritic cells (FDCs) play a crucial role in the process of SHM by presenting antigens to B cells within the germinal centers. FDCs retain antigens on their surface, allowing B cells to interact with them repeatedly. This interaction is vital for the selection of high-affinity B cells and the subsequent clonal expansion and differentiation into plasma cells and memory B cells.
