In the context of skin histology, EGF is pivotal for epidermal homeostasis. It accelerates the proliferation of keratinocytes, the predominant cell type in the epidermis, and stimulates the synthesis of DNA, RNA, and proteins. This leads to enhanced wound healing and tissue repair. EGF also promotes the formation of the stratum corneum, the outermost layer of the skin, which is vital for the skin's barrier function.