What is the Role of Calsequestrin in Muscle Contraction?
Calsequestrin's primary role in muscle contraction is to act as a calcium buffer within the sarcoplasmic reticulum. During muscle excitation, calcium ions are released into the cytoplasm, triggering the interaction between actin and myosin filaments. This interaction is crucial for muscle contraction. After contraction, calcium ions are pumped back into the sarcoplasmic reticulum, where calsequestrin binds them, reducing the free calcium ion concentration and allowing the muscle to relax.
