What is the Role of AID in Class Switch Recombination?
Class switch recombination (CSR) allows a B cell to change the isotype of the antibody it produces without altering the antigen specificity. AID initiates CSR by creating double-strand breaks in the DNA at specific switch regions. These breaks are then repaired through a process that changes the constant region of the antibody gene, enabling the production of different antibody isotypes such as IgG, IgA, or IgE.
