In histological contexts, AhR plays a crucial role in tissue homeostasis, differentiation, and immune response. For instance:
- Skin: AhR is involved in skin barrier function and keratinocyte differentiation. Dysregulation of AhR signaling has been linked to skin disorders like psoriasis and atopic dermatitis. - Liver: AhR is critical in liver function, influencing both detoxification processes and hepatocyte proliferation. - Immune System: AhR modulates the development and function of various immune cells, including T cells, dendritic cells, and macrophages. It has been implicated in the regulation of immune tolerance and inflammation.
