What Role Does Immunohistochemistry Play in Diagnosing Cutaneous Lesions?
Immunohistochemistry (IHC) is an invaluable tool in the histological examination of cutaneous lesions. By using specific antibodies, IHC can identify particular antigens expressed by cells within a lesion, aiding in the differentiation between benign and malignant processes. For example, melanomas often express markers such as S-100, HMB-45, and Melan-A, whereas basal cell carcinomas may express Ber-EP4. The use of IHC enhances diagnostic accuracy, particularly in challenging cases.
