From a histological perspective, ketogenesis can affect the liver and other tissues in several ways. In the liver, prolonged ketogenesis can lead to the accumulation of fat, resulting in a condition called hepatic steatosis or fatty liver. This condition can be observed under the microscope as large lipid droplets within hepatocytes. In other tissues, the use of ketone bodies for energy can be seen in the mitochondria, which may show increased activity and changes in structure due to the high metabolic demand.
