What is the Histological Appearance of Hemoglobinopathies?
Histologically, hemoglobinopathies can be identified by examining blood smears under a microscope. In Sickle Cell Disease, the blood smears reveal sickle-shaped red blood cells. In thalassemia, the red blood cells appear microcytic and hypochromic, indicating that they are smaller and have less hemoglobin than normal. Additionally, bone marrow biopsy in thalassemia may show increased erythropoiesis with a shift towards immature red blood cell precursors.
