The HER2 receptor, also known as human epidermal growth factor receptor 2, is a protein that is involved in the regulation of cell growth. It is a member of the epidermal growth factor receptor (EGFR) family and is encoded by the ERBB2 gene. HER2 is a transmembrane tyrosine kinase receptor, which means it spans the cell membrane and can phosphorylate tyrosine residues, initiating a cascade of downstream signaling pathways.