Dysregulation of FKBP12 has been linked to several diseases. For example:
Neurodegenerative Diseases: Altered FKBP12 function is implicated in diseases like Alzheimer's and Parkinson's, where protein misfolding plays a key role. Cardiovascular Diseases: Abnormal FKBP12 activity can affect heart muscle contraction and has been linked to heart failure. Cancer: Given its role in cell signaling and growth, FKBP12 dysregulation can contribute to the uncontrolled cell proliferation seen in cancers.
