The clinical significance of PP cells lies in their role in various pancreatic disorders and diseases. Anomalies in the number or function of PP cells can be associated with several conditions:
Pancreatic cancer: Altered levels of pancreatic polypeptide can be an indicator of pancreatic tumors. Diabetes mellitus: Dysfunction in islet cells, including PP cells, can contribute to the development of diabetes. Hypoglycemia: Overproduction of pancreatic polypeptide can affect glucose metabolism, leading to hypoglycemia.
