While lipofuscin accumulation is generally considered a marker of cellular aging, excessive accumulation can be associated with certain pathological conditions. For example, lipofuscinosis refers to a group of inherited lysosomal storage disorders where abnormal amounts of lipofuscin accumulate, leading to cellular dysfunction and disease. In addition, high levels of lipofuscin in neurons are commonly observed in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.
