What is the Clinical Significance of Enteroendocrine Cells?

Enteroendocrine cells are critical in maintaining gut homeostasis and metabolic regulation. Dysfunction in these cells can lead to various clinical conditions. For instance, overproduction of gastrin by enteroendocrine cells can result in Zollinger-Ellison syndrome, characterized by excessive gastric acid secretion and peptic ulcers. Additionally, enteroendocrine cells are involved in the regulation of appetite and energy balance, making them potential targets for obesity and diabetes treatments.