What is the clinical significance of CTLA-4 in histopathology?
In histopathology, the expression of CTLA-4 can have significant clinical implications. For instance, in cancer immunotherapy, CTLA-4 inhibitors such as ipilimumab are used to enhance the immune response against tumors. By blocking CTLA-4, these therapies aim to boost T cell activity and improve the body's ability to fight cancer. Additionally, abnormal CTLA-4 expression can be associated with autoimmune diseases and other immune disorders.
