Ankyrin R, also known as ankyrin-1, is a crucial protein that plays a significant role in the structural integrity of red blood cells (RBCs). It is a member of the ankyrin family of proteins, which are involved in the attachment of integral membrane proteins to the spectrin-actin cytoskeleton. Specifically, Ankyrin R is encoded by the ANK1 gene and is predominantly found in erythrocytes but also expressed in other tissues.