Histological stains are used to enhance the contrast of tissue samples under a microscope. Common stains include Hematoxylin and Eosin (H&E), which stains nuclei blue and cytoplasm pink, and Masson's Trichrome, which differentiates muscle, collagen, and fibrin. Specialized stains like Periodic Acid-Schiff (PAS) help visualize carbohydrates and glycogen.